WebMerle arises from an unstable SINE insertion (which we term the "M*" allele) that disrupts activity of the pigmentary gene PMEL, leading to mottled or patchy coat color. Dogs with an M * m result are likely to be phenotypically merle or could be "phantom" merle, that is, they have a merle allele that does not affect coat color. WebSep 20, 2024 · The dam–AF762 –is distinguished by a Mh phenotype as described in #1 - “Minimal Merle”. The two offspring–AF758 and AF759 both have a Mh phenotype as described in #2—The more classic pattern that is often referred to as “Herding Harlequin“. Both dam and offspring have the same length of Mh—271 bp. (TIF) …
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WebApr 8, 2024 · Merle is a coat pattern found in Australian Shepherds and a number of other dog breeds. The phenotype is inherited as an autosomal, incompletely dominant trait. The Merle gene creates mottled patches of color in a solid or piebald coat, blue or odd-colored eyes, and can affect skin pigment as well. WebMerle arises from an unstable SINE insertion (which we term the "M*" allele) that disrupts activity of the pigmentary gene PMEL, leading to mottled or patchy coat color. Dogs with an M * m result are likely to be phenotypically merle or could be "phantom" merle, that is, they have a merle allele that does not affect coat color. thienlongbatbo vng
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WebMerle is not naturally occurring in goldens or poodles, so something else has been mixed in. It carries a lot potential negative health defects when two Merle dogs are bred together, and it does not always appear phenotypically in some colors, so it is opens the door to accidentally breeding two Merle dogs together. WebSep 20, 2024 · In 2006, the Merle (M) locus was mapped to the SILV gene (aka PMEL) with a SINE element in it, and the inserted retroelement was proven causative to the Merle phenotype. Mapping of the M locus was a genetic breakthrough and many breeders started implementing SILV SINE testing in their breeding programs. http://www.doggenetics.co.uk/series.html sainsburys olney opening hours