Mycothiol synthase
Web31 aug. 2007 · Identification of the mycothiol synthase gene (mshD) encoding the acetyltransferase producing mycothiol in actinomycetes. Koledin T, Newton GL, Fahey … Web28 mrt. 2024 · M. tuberculosis (Mtb) produces mycothiol (MSH) in place of glutathione as the most abundant low molecular weight thiol. MSH and associated enzymes (e.g. mycothiol-S-transferase, MST) are thought to play pivotal roles in cellular… Expand discovery.ucl.ac.uk Save to LibrarySave Create AlertAlert Cite Share This Paper
Mycothiol synthase
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WebThe Substrate-Induced Conformational Change of Mycobacterium Tuberculosis Mycothiol Synthase. J.Biol.Chem., 281:2795-2802, 2006. Cited by . PubMed: 16326705 DOI: 10.1074/JBC.M510798200 PDB entries with the same primary citation: Experimental method: X-RAY DIFFRACTION Structure validation. Download full validation report. … Web5 mrt. 2003 · Mycothiol has antioxidant activity as well as the ability to detoxify a variety of toxic compounds. Because of these activities, MSH is a candidate for protecting Mycobacterium tuberculosis from inactivation by the host during infections as well as for resisting antituberculosis drugs.
WebTIGR03448 (PSSM ID: 132489): Conserved Protein Domain Family mycothiol_MshD, Members of this family are MshD, the acetyltransferase that catalyzes the final step of … Web2 feb. 2016 · The first system includes mycothiol synthase MshC, a class I CysRS paralogue; biotin-protein ligase BirA, a class II SerRS paralogue; and PoxA, a class II LysRS paralogue. MshC activates Cys with ATP, forming Cys~AMP, and then transfers the activated Cys to an amino group of glucosamine in the mycothiol biosynthetic pathway …
Web2 jan. 2024 · Language links are at the top of the page across from the title. WebTIGR03450 (PSSM ID: 132491): Conserved Protein Domain Family mycothiol_INO1, This enzyme, inositol 1-phosphate synthase as found in Actinobacteria, produces an essential precursor for several different products, including mycothiol, which is a glutathione analog, and phosphatidylinositol, which is a phospholipid
Web2 feb. 2016 · Aminoacyl-tRNA syntheases (AARSs) carry out two important functions in translation of the Genetic Information [ 1, 2]: Chemical Activation and Information Transfer. The Chemical Activation function involves a reaction between a carboxyl group of an amino acid (AA) and ATP, affording an aminoacyl~adenylate (Reaction I ): (I)
WebMycothiol (MSH) is an intracellular reducing agent used by mycobacteria (e.g., Mycobacterium tuberculosis) to protect against oxidative damage, a role similar to that … short tail mouseWeb30 aug. 2024 · Mycobacterium abscessus has been recognised as a dreadful respiratory pathogen among the non-tuberculous mycobacteria (NTM) because of misdiagnosis, prolonged therapy with poor treatment outcomes and a high cost. This pathogen also shows extremely high antimicrobial resistance against current antibiotics, including the anti … short tail mud motorsWeb1 feb. 2014 · The S-mycothiolome includes the methionine synthase (MetE), the maltodextrin phosphorylase (MalP), the myoinositol-1-phosphate synthase (Ino1), … short tail mud motor plansWebMycothiol synthase is an enzyme with systematic name acetyl-CoA:desacetylmycothiol O-acetyltransferase. This enzyme catalyses the following chemical reaction This enzyme … saphore italian halifaxWeb21 apr. 2006 · In mycobacteria, mycothiol (MSH) serves as the major systemic protectant. MSH (1 d - myo -inosityl 2- ( N -acetyl- l -cysteinyl) amido-2-deoxy-α- d -glucopyranoside), is the dominant low molecular-weight thiol, reducing agent, and storage form of cysteine, produced by mycobacteria and a number of other actinomycetes [ 10]. short tail numbersWeb1 feb. 2014 · Mycothiol (MSH) is essential for growth and survival of Mycobacteria • MSH is an important cellular anti-oxidant protecting Mycobacteria from reactive oxygen species • tuberculosis Abstract Tuberculosis (TB) is the world’s second commonest cause of death next to HIV/AIDS. short tail of a rabbit crossword clueWebThe genes encoding the different enzymes that are involved are scattered throughout the genome, and do not form an operon. The bacteria that synthesize mycothiol use it as a protectant against electrophilic compounds as well as for detoxification of reactive oxygen and nitrogen species [ Hand05 ]. short tail of a rabbit