Witryna5 maj 2008 · Inhibition of β-TrCP function sensitizes human ... (2001). C-MYC and IGF-II mRNA-binding protein (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors. ... (2007). CRD-BP shields c-myc and ... Witrynapreferentially to distinct CRD-BP KH domains. The novel insights revealed in this study have important implications on the understanding of the oncogenic mechanism of CRD-BP a well as in the future design of inhibitors against CRD-BP function. Coding region determinant-binding protein (CRD-BP; mouse), also known as IMP1 (human),

Transcriptional Regulation of CRD-BP by c-myc - PMC

Witryna15 cze 2006 · CRD-BP function seems to be important for the pathogenesis. of human colorectal cancer, a disease in which the activation of. b ... (CRD-BP/IMP-1) in benign and malignant mesenchymal tumors. Int. J. WitrynaUpper panel, analysis by gel electrophoresis of CRD-BP/IMP1 amplicons. 1, BM CD34 cells cultured in plain medium; 2, medium containing 5azaC; 3, medium containing the cytokines mixture; 4, medium ... primatologists or paleoanthropologists

Transcriptional Regulation of CRD-BP by c-myc: Implications for c …

WitrynaCRD-BP was shown to upregulate the expression of different genes including c-myc, 13 β-TrCP1, 10 MDR1, 14 and GLI1. 15 It was also shown to be necessary for proper … Witryna1 paź 2010 · Europe PMC is an archive of life sciences journal literature. Introduction. CRD-BP, the coding region determinant binding protein, also known as insulin-like growth factor 2 mRNA-binding protein 1 (IMP-1 or IGF2BP-1), is a multifunctional RNA binding protein involved in different processes such as mRNA turnover, translation control, … Witryna7 sty 2011 · CRD-BP was shown to upregulate the expression of different genes including c-myc, 13 β-TrCP1, 10 MDR1, 14 and GLI1. 15 It was also shown to be necessary for proper cell adhesion, cytoplasmic spreading, and invadopodia formation through its binding to the 3′UTR of CD44 mRNA and stabilization of the mRNA. In … play goldfish slot machine online free