Daptomycin dosing for obese patients
WebSep 4, 2024 · A case series of long-term high-dose daptomycin (mean dose 8 mg/kg TBW for at least 14 days) described 3 of 61 patients, 2 of whom … WebIssues such as dosing strategies in obese patients, safety profiles in daily dosages exceeding 3 g, continuous infusion strategies, and renal failure are some examples where insufficient data precluded adequate coverage. ... This has been demonstrated for vancomycin , aminoglycosides , daptomycin , linezolid , and also β-lactams [126,127 ...
Daptomycin dosing for obese patients
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WebDaptomycin pharmacokinetics were studied in adult volunteers who were moderately obese (body mass index [BMI] = 25–39.9 kg/m2) or morbidly obese (BMI 40 kg/m2) and a matched (gender, age, renal function) nonobese (BMI between 18.5 …
Web2. In adult patients, cefazolin (2 g if <120 kg, 3 g if ≥120 kg) and vancomycin (1 g if <80 kg, 1.5 g if ≥80 kg) dosing is based on weight. Adult patients <50 kg should refer to Patients <50 kg (Adult and Pediatric) Dosing recommendations for dosing. Weight-based dosing is recommended for all antibiotics in patients <50 kg. 3. Webaggressive dosing is recommended for patients being dialyzed longer hours/day and/or for severe infections. For patients on continuous SLED, dose as CrCL >50mL/min. Monitor patients closely for therapeutic failure and drug toxicity. £No clear recommendation in literature. Recommendations based on estimated CrCL 15-50mL/min, depending on …
WebFor bolus doses, use total body weight. For continuous infusions, use ideal body weight. In obese patients, midazolam volume of distribution increases proportionally to body … WebFeb 23, 2024 · Obese patients received a dose of 0.6 mg/kg while non-obese subjects received a fixed dosage of 40 mg (approximately 0.5 mg/kg based on reported total body weight). Volume of distribution was closely related …
WebDaptomycin dosing intensified throughout the study period. Conclusion: The two daptomycin dosing cohorts were statistically equivalent for both clinical failure and 90 …
WebMay 30, 2024 · Per the US Food and Drug Administration labeling, daptomycin is recommended to be dosed based on total body weight (TBW). This involves … jelena antic jagodinaWebMay 27, 2024 · - Limited PK data in obese humans based on 1 - 2mg/kg single dose PK ; in general pop PK studies, linear increase in Vd and CL with weight - PK reported to be non-linear at >5mg/kg doses (max Cmax and AUC at 10mg/kg/day) - Safety data: at doses … jelena aparacWebDaptomycin Dosing and Use Guidelines Dosing: Soft tissue infection = 4 mg/kg every 24 hours Staphylococcus aureus bacteremia, other deep-seated infections = 6 mg/kg … jelena anžujskaWebCurrent medications include daptomycin 600 mg intravenous (IV) daily (6 mg/kg/Q24 hour), rifampin 300 mg per oral (PO) twice daily, aspirin, lisinopril, pantoprazole, tamsulosin, and PO hydrocortisone, levothyroxine, and subcutaneous heparin. jelena armasWebMar 7, 2024 · Daptomycin pharmacokinetics and safety following administration of escalating doses once daily to healthy subjects. Antimicrob Agents Chemother 2003; … lahm tmWebMar 10, 2024 · Daptomycin (Cubicin or generics): Reconstitute single-dose vial containing 500 mg of daptomycin with 10 mL of 0.9% sodium chloride injection to provide solution containing 50 mg/mL. Add the diluent using beveled sterile transfer needle (≤21 gauge) or needleless device; direct diluent toward vial wall. jelena alekszandrovna kuzminaWebAug 8, 2024 · One trial compared obese patients who received actual body weight (ABW) vs adjusted body weight (AdjBW) dosing. The most common indications for daptomycin in … jelena arambasic